The region lies between approximately latitude 15° 40' and 18° 30' north and between longitude 94° 15' and 96° 15' east. It has an area of 35,140 square kilometres (13,566 sq mi). The population is more than 6.5 million, making it the most populous of Burma’s states and regions. According to the 2014 Burmese National Census the population of the Ayeyarwady Region was 6,184,829.

Ayeyarwady Region is flanked by the RakhineYoma (Arakan Mountains) range in the west. Large areas have been cleared for paddy cultivation, leading to its preeminent position as the main rice producer in the country, a position it has retained into the 21st century.

It has also a number of lakes. Of the rivers branching out from the mighty Ayeyarwady, Ngawun, Pathein and Toe are famous.

The capital city of Ayeyarwady division is Pathein.

Chaungtha Beach and Ngwesaung Beach are popular resorts for both foreigners and the Burmese. They are in the west of the Ayeyarwady Region, an hour from Pathein city and four hours from Yangon city by road.

Ayeyarwady Region is heavily forested and wood products are an important component of the economy. The principal crop of Ayeyarwady Region is rice, and the division is called the “granary of Burma.” In addition to rice, other crops include maize, sesame, groundnut, sunflower, beans, pulses, and jute. Fishery is also important; Ayeyarwady Region produces fish, prawn, fish-paste, dry fish, dry prawn, and fish sauce.

Ayeyarwady Region also has considerable tourist potential. The city of Pathein has numerous historic sights and temples. Outside Pathein are the beach resorts of Chaungtha Beach and the lake resort of Inye Lake. Inye lake is located in Kyonpyaw township, 59 miles (95 km) north east of Pathein. Inye lake is also well known for fishery, as the major supplier of fresh water fish. Chaungtha is located in Pathein township. However, hotel and transportation infrastructure is still very poorly developed.